July 20, 2024

Trevi Therapeutics onboards David Clark as CMO

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David Clark, MD, MRCP

Trevi Therapeutics, Inc. a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio (oral nalbuphine ER) for the treatment of chronic cough in adults with idiopathic pulmonary fibrosis (IPF) and other chronic cough indications, and for the treatment of prurigo nodularis, recently announced the appointment of David Clark, MD, MRCP, as Chief Medical Officer (CMO). Dr. Clark will join Trevi’s executive team and be responsible for the strategy and execution of Haduvio’s clinical programs.

“I am pleased to welcome David to our executive leadership team,” said Jennifer Good, President and CEO of Trevi Therapeutics. “David brings his respiratory background to Trevi through his medical training and drug development experience. In addition, we believe his strong track record as a biotech CMO and successful delivery of Phase 3 programs will enable David to play a key role as we progress the development of Haduvio in our targeted indications.”

Dr. Clark joins Trevi with over 25 years of global clinical development experience in big pharma and biotech. Most recently, Dr. Clark served as Chief Medical Officer at Allena Pharmaceuticals, leading the Company’s clinical development, regulatory and medical affairs teams. Prior to that, he served as Chief Medical Officer for various companies, including Aldeyra Therapeutics, Wilson Therapeutics, and NormOxys. As Chief Medical Officer, Dr. Clark has strategized and supported teams from clinical translation through Phase 3. He has also held senior leadership positions at TransTech Pharma, Pfizer, SmithKline Beecham, and GlaxoSmithKline. Dr. Clark holds a Bachelor of Medicine and Surgery (MD) from the University of Edinburgh Medical School, and a Membership of the Royal College of Physicians (MRCP). Dr. Clark also completed a research fellowship in respiratory medicine in the United Kingdom.

“Idiopathic pulmonary fibrosis is a very debilitating disease for patients in which cough plays a central role,” said Dr. Clark. “I was impressed with the results from the Phase 2 CANAL trial and believe Haduvio’s centrally acting mechanism has the potential to significantly impact this disease. I look forward to progressing Haduvio through development for the treatment of chronic cough in adults with IPF, as well as initiating development work in other serious chronic cough conditions.”

Dr. Thomas Sciascia, MD, the co-founder of Trevi Therapeutics, previously served as Trevi’s Chief Medical Officer and will be transitioning to Chief Science Officer. His background as a board-certified neurologist and his experience with the development of Haduvio to date provides a deep understanding of Haduvio’s mechanism. Dr. Sciascia’s extensive knowledge of Haduvio will be applied to strengthen the continued exploration of Haduvio in serious chronic cough conditions.

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